Study details

Epidemiological study on low gestational age infants 2

EPIPAGE 2

Unknown

More than 10 years are passed since the beginning of the EPIPAGE study. The evolutions occurred since justify the creation of a new cohort. The main objectives of EPIPAGE 2 are: 1) Study the becoming of extremely premature children and their families 2) The evaluation of care organization effects and medical practice on premature children’s health and development 3) Research of causes and consequences of prematurity 4) Study the path of the different families and the decisions process at the moment of birth and intensive care 5) The needs analysis of medical and educational care One of the originalities of the study is to have permitted the creation of complementary and multidisciplinary projects, in order to reply and deepen to question difficult to handle on the children of the cohort. These projects, based on the same structure of EPIPAGE 2, needs additional investigations and an own funding. A total of 8 studies have been developed in the field of brain imaging, bio-markers, nutrition, mother-child interaction and ethics: - ETHIQUE (decision process leading to survival or death of children born between 22 and 26 weeks of amenorrhea) - EPIFLORE (study of the introduction of the intestinal microbiota) - EPIRMEX (Study of the executive functions and of the language development, depending on anomalies detected through NRM) - BIOPAG (Identification of the early bio-markers of pathologies from an umbilical cord sample (DNA, RNA) - OLIMPE (Study of the existing links between the quality of early mother-child interactions and the neural and developmental becoming) - CHORHIST (Research of chorioamniontides through anatomo-pathological analysis of placenta) - EPINUTRI (Study of the associations of the intake of polyunsaturated fatty acids, iron intake and neurological becoming of extremely premature children) - EPIPAIN 2 (treatment of painful movements in neonatal intensive care. RE-CO-NAI platform EPIPAGE 2 is one of the two cohorts constituting the RE-CO-NAI platform, together with the ELFE cohort. The general objective of this platform is to create an infrastructure offering the measures required for collecting, highly secured storage and distribution of data concerning the pregnancy, the birth and the child. The research platform consist of cohorts of infants followed since birth will allow to study, in a global and multidisciplinary way, the stakes on health, development and socialization of children. It will in addition provide substantial visibility in the world of academic research (French and international), but also with regards to bodies, associations, and industries that have interests in children. As such, it will allow for an optimized valorization of the data collected and will facilitate the dissemination of data.

Perinatality neonatal mortality and morbidity (respiratory neurological infectious metabolic) neural development (motor sensory cognitive) growth) handicaps

Gynaecology and obstetrics Paediatrics

Biological determinants: Genetic predisposition Biological determinants

France

Individus

Etude observationnelle

Cohorte

Evénements de santé/morbidité
Evénements de santé/mortalité
Qualité de vie/santé perçue